Doctor Pharmacy

XANAX XR

Generic Name and Formulations:

Alprazolam 0.5mg, 1mg, 2mg, 3mg; ext-rel tabs.

Anxiety/OCD:

Indications for XANAX XR:

Panic disorder.

Adult Dose for XANAX XR:

Swallow whole. ≥18yrs: initially 0.5–1mg once daily, preferably in the AM; increase at intervals of at least 3–4 days by up to 1mg/day. Taper no faster than by 0.5mg every 3 days. Usual range: 3–6mg/day; max 10mg/day. Elderly or debilitated: initially 0.5mg/day. Switching from immediate-release alprazolam: give total daily dose of immediate-release once daily, preferably in the AM.

Children Dose for XANAX XR:

<18yrs: not recommended.

Pharmacological Class:

Benzodiazepine.

Contraindications:

Acute narrow-angle glaucoma. Concomitant itraconazole, ketoconazole.

Warnings/Precautions:

Not for use in untreated open-angle glaucoma. Reevaluate periodically. Change dose gradually. Withdrawal symptoms on abrupt cessation or dose reduction. Suicidal ideation. Psychosis. Mania. Renal, cardiovascular, hepatic, pulmonary dysfunction (monitor). Obesity. Elderly. Debilitated. Labor & delivery. Pregnancy (Cat.D), nursing mothers: not recommended.

Interactions:

See Contraindications; other azole antifungals: not recommended. Potentiates CNS depression with alcohol, psychotropics, anticonvulsants, other CNS depressants. Potentiated by CYP3A inhibitors; reduce alprazolam dose; caution with cimetidine, nefazodone, fluvoxamine; caution with weaker CYP3A inhibitors (eg, fluoxetine, propoxyphene, oral contraceptives). Antagonized by CYP3A inducers (eg, carbamazepine). May increase levels of imipramine, desipramine.

Adverse Reactions:

CNS depression; impaired memory, coordination, or attention; dysarthria, ataxia, arthralgia, dyspnea, paradoxical excitement, increased salivation, withdrawal seizures, tremors, decreased libido, sexual dysfunction.